New fungal genomics paper published

A new paper has been published in PLoS Genetics in collaboration with my former colleagues at the University of Kent in the Buscaino lab.

Stress combined with loss of the Candida albicans SUMO protease Ulp2 triggers selection of aneuploidy via a two-step process

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The paper explores the balance between genome stability and instability in driving genetic diversity and evolution.

It highlights how the human fungal pathogen Candida albicans utilizes genome variation to adapt to hostile environments and resist antifungal drugs.

By identifying the SUMO protease Ulp2 as a key regulator of genome integrity, the study reveals how its deletion enhances genome instability and variation, leading to adaptive segmental aneuploidies under combined stress conditions.