New mycoprotein pre-print available

Our new mycoprotein pre-print is now available on Research Square.

Mutation of the LRG1 Rho-GAP gene is responsible for the hyper branching C-variant phenotype in the Quorn mycoprotein fungus Fusarium venenatum A3/5

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Our latest research investigated the cause of undesirable colonial variants (C-variants) that appear during Quorn mycoprotein production.

Through whole genome sequencing, mutations were identified in an LRG1 ortholog in C-variant isolates, which was not observed in wild-type strains.

Introducing these LRG1 mutations into wild-type isolates using CRISPR/Cas9 successfully reproduced the C-variant morphology, confirming the gene’s role in this trait.